The Santa Maria River (Tagalog: Ilog Santa Maria, Spanish: Río Santa Maria), is a river in the province of Bulacan, Philippines. Stretching for 31 kilometres (19.3 mi), it bisects the municipalities of Santa Maria, Bocaue and the city of San Jose del Monte. Its major tributaries are the Caypombo River and an unnamed river in San Jose del Monte.

Santa Maria River
Santa Maria River near Sitio Macaiban, Barangay Poblacion, Santa Maria
Native name	Ilog ng Santa Maria  (Tagalog)
Location
Country	Philippines
Region	Central Luzon
Province	Bulacan
City/municipality	Santa Maria San Jose del Monte Bocaue Bulakan
Physical characteristics
Source	Sierra Madre mountains
• location	Norzagaray, Bulacan
Mouth
• location	Bulakan
• coordinates	14.76583°N 120.91481°E / 14.76583; 120.91481
• elevation	0 m (0 ft)
Length	31 km (19 mi)
Basin features
Tributaries
• left	Caypombo River (Pulo River), Santa Clara River